Injecting semaglutide, tirzepatide, or other once-weekly peptide medications is a straightforward process when done correctly. These therapies are typically administered with a prefilled injection pen designed for safe and convenient self-use.

General Guidelines

Choose the right injection site:

  • Common areas include the abdomen (at least 2 inches away from the belly button), the front of the thighs, or the outer upper arm (if someone else assists).
  • Rotate injection sites each week to prevent skin irritation.

Prepare the pen:

  • Check the expiration date.
  • Inspect the solution — it should be clear and colorless. Do not use if cloudy or if particles are visible.

Clean the injection area:

  • Use an alcohol swab to disinfect the skin before injecting.

Preparation

Read the instructions

that come with your medication pen for specific details.

Gather supplies:

  • Prefilled injection pen (semaglutide, tirzepatide, or similar)
  • Alcohol swab
  • Sharps disposal container

Check the pen:

  • Confirm the pen has not expired.
  • Ensure the solution is clear and colorless.

Injection Sites

You can inject into:

  • Abdomen – at least 2 inches away from the belly button
  • Thighs – front or outer area
  • Upper Arm – outer arm, usually with assistance

⚠️ Rotate injection sites to minimize the risk of irritation or skin changes.

Step-by-Step Injection

Attach a new needle

  • Twist or push the needle onto the pen (depending on pen type).
  • Remove both the outer and inner needle caps.

Prime the pen (if required)

  • Some pens require priming. Turn to a small test dose and press the button to release a drop of medication.

Set the dose

  • Turn the dial on the pen to the prescribed dose (e.g., 0.25 mg, 0.5 mg, or as directed by your healthcare provider).

Inject the medication

  • Pinch the skin gently at the injection site.
  • Insert the needle at a 90-degree angle.
  • Press and hold the injection button until the dose counter returns to “0.”
  • Keep the needle in place for 6–10 seconds to ensure the full dose is delivered.

Dispose of the needle

  • Remove the needle and place it in a sharps container.

Store the pen

  • Keep unopened pens refrigerated.
  • Opened pens can usually be stored at room temperature (up to 86°F / 30°C) or in the refrigerator, depending on manufacturer instructions, for up to 56 days.

Aftercare

  • Check the injection site for redness, swelling, or bleeding.
  • Do not inject into areas that are bruised, tender, or scarred.
  • Use a new needle for every injection.
  • Never share your injection pen, even if you replace the needle.

Key Tips

  • Inject at the same time each week to stay consistent.
  • Always follow the dosing schedule prescribed by your healthcare provider.
  • If you have difficulty or questions, ask your doctor or pharmacist for a demonstration.